Viartril®-S Glucosamine Sulfate
Support for Healthy Joint Function
Hong Kong Reg. No.: HK-55772 (500 capsules); HK-36756 (30 sachets)
The role of glucosamine sulfate in halting or reversing joint degeneration appears to be directly due to its ability to act as an essential substrate for the biosynthesis of glycosaminoglycans (GAGs) and hyaluronic acid, the chemical backbone needed to form the proteoglycan cartilage found in the structural matrix of joints. Glucosamine also inhibits cartilage breakdown by chondrocytes. Recent studies confirm that glucosamine is bioavailable both systemically and in the joints after oral administration of crystalline glucosamine sulfate in osteoarthritis patients (Persiani, 2007).
Rottapharm, the European patent holder and manufacturer of this product, sponsored two large (at least 100 patients per group), three-year, placebo-controlled clinical trials of Viartril-S. Both of these studies demonstrated a clear benefit for glucosamine treatment (Reginster, 2001). There was not only an improvement in symptoms, but also an improvement in joint space narrowing on radiographs. These results indicate that glucosamine can actually help prevent the destruction of cartilage that is the hallmark of osteoarthritis, unlike pain relievers such as non-steroidal anti-inflammatory drugs (NSAIDs) (Pavelká, 2002). Successful treatment of osteoarthritis should effectively control pain and slow down or reverse the progression of the degeneration. Research proves glucosamine sulfate is capable of satisfying both of these criteria. It generally takes around four weeks before improvements in symptoms are noticed when taking glucosamine, and longer for radiographic changes.
The legal status of glucosamine sulfate in Hong Kong is that it must be registered as a drug by the Hong Kong Department of Health. Our products are registered (as indicated by the registration numbers HK-55772 and HK-36756) and approved for the claim that it is medically indicated for the treatment of symptoms of osteo-arthritis (pain and function limitation).
Most of the positive scientific research conducted on glucosamine has been done on glucosamine sulfate, and it has been found to be conclusively more effective than glucosamine HCl, since the sulfate part of the salt is needed by the body to produce cartilage as well.
Recent European League Against Rheumatism practice guidelines for knee osteoarthritis give glucosamine sulfate the highest level of evidence and strength of the recommendation.
Adverse effects, which are usually mild and infrequent, include stomach upset, constipation, diarrhoea, headache, and rash. It is contraindicated in persons with allergy to shellfish.
Each sachet contains: Crystalline Glucosamine Sulphate 1884 mg, equivalent to 1500 mg of Glucosamine Sulphate, Excipients q.s. to 3950 mg.
Each capsule contains: Crystalline Glucosamine Sulphate 628 mg, equivalent to 500 mg of Glucosamine Sulphate and 128 mg of Sodium Chloride; Talc, Magnesium stearate.
500 mg Capsules: 1 capsule 3 times daily, preferably at meals.
1500 mg Powder: Dissolved in water taken once daily, preferably at meals.
500 mg Capsules (500s) and 1500 mg Powder (30 sachets). Sachets are contraindicated in persons with phenylketonuria.
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