INL Articles - CBC & CBD Patient Outcomes

CBC and CBG join CBD in an exciting joint role for better patient outcomes

The therapeutic potential of the phyotcannabinoid CBD from hemp is well documented. Anxiety, pain management, osteoporosis, skin conditions and sleep can be assisted by CBD’s interaction with the endocannabinoid system.

In this edition of the newsletter, we will be looking at Cannabichromene (CBC) and Cannabigerol (CBG) from hemp and the new horizons for treatment they offer such as osteoporosis prevention, anti-microbial actions along with amplifying important neurotransmitter production such as anandamide for sleep and stress-management.

Cannabingerol (CBG) is often referred to as the “stem cell” or “mother” of cannabinoids

CBG is considered to be one of the main precursors from which other cannabinoids are synthesised. This makes it one of the constituents in hemp garnering interest as researchers extend their focus beyond CBD.

Non-psychoactive similarly to CBD, CBG has been shown to have a promising role in pain and the management of inflammation but also as an anti-bacterial agent potentially with methicillin-resistant Staphylococcus aureus (MRSA) strain of clinical relevance. (1)

CBG has also been found to be a strong component of what’s often referred to as the “entourage effect” on the endocannabinoid system. This can be seen in it’s action on the brain boosting the brain’s “bliss” molecule anandamide. CBG also inhibits the uptake of GABA, which then sees a decrease in anxiety and muscle tension - similar to CBD’s effects.

One of the newer horizons for the use of CBG is in the use of glaucoma for older patients. When studied alongside THC it was found that CBG had a two to three fold increase in aqueous outflow facility, an outcome that suggests that it’s therapeutic potential for CBG’s and other cannabinoid’s use in glaucoma is warranted. (2)

Often in lower doses when found in CBD formulations, movements towards creating strains of hemp higher in CBG, which is often higher when the plants are harvested earlier may see options for the use of different standardised hemp formulas for different indications. Definitely a watch-this-space situation from an emerging evidence point of view.

Cannabichromene (CBC) works on the CB2 receptor synergistically with CBD for pain and inflammation and stem cells in the brain

CBC is one of the most abundant phytocannabinoids found in hemp. Whilst CBD is still considered to be the prominent anti-inflammatory constituent, interest regarding CBC’s binding with TRPV1 and TRPA1 receptors to attenuate pain perception is mounting. (3) Animal studies have also shown CBC has an action on pain in a different manner to the one common NSAIDs exert while exhibiting none of the side effects, showing exciting synergistic anti-inflammatory potential with the other phytocannabinoids. (4)

Further preclinical studies into the action of CBC within the brain have offered a different viewpoint on the neurodevelopmental and neuroprotective mechanisms of non-active phytocannabinoids.

One study in particular looked at the role of CBC together with CBD and CBG on neural stem progenitor cells (NSPCs). As you might be able to derive from the name, NSPCs are the stem cells of the brain and precursors to neurons, oligodendrocytes, and astrocytes. (5)

Researchers in this study found that CBC was connected to higher concentrations of NSPCs and played a role in the direction that these cells took to create other brain cells, more specifically astrocytes. The non-psychoactive phytocannabinoids have long been known to have a neuroprotective action but this new role with CBC and astrocytes sees therapeutic potential in neurodegenerative diseases along with the potential prevention of such diseases as more is found out about dosing, timing and application.

There’s definitely a lot more to learn about the use of phytocannabinoids for the every day health of our patients. When we focus on specific constituents within a whole herb in this case, cannabis, sometimes we can lose site of the role that the constituents can be synergistic or as we have looked at in this article, on specific conditions that we might not have thought of.

This then points to why broad spectrum CBD supplements are valued over isolated CBD extracts for the benefit of our patients. The CBD is getting some help from it’s friends!