Is your client stressed, with signs of inflammatory issues? Consider CBD for calming support.

CBD is the plant-based endocannabinoid from hemp. Its full name is Cannabidiol.

CBD is one of the main pharmacologically active phytocannabinoids [1]. It is non-psychoactive, but has many beneficial pharmacological effects, including anti-inflammatory and antioxidant effects. [4]. In addition, it belongs to a group of compounds with anxiolytic, antidepressant, antipsychotic, and anticonvulsant properties, among others [3].

There’s a lot of interest in CBD, both in the public domain as well as in research communities. For the researchers, it is because CBD from hemp plants is active on the “endocannabinoid system”, which has receptors in the central nervous system and many other tissues.  Endocannabinoids, such as CBD, produce a wide variety of protective and harmonising influences to many internal organs and functions, which are the subject of ongoing studies.

As reported in the report Cannabidiol as a Potential Treatment for Anxiety Disorders; “Existing preclinical evidence strongly supports CBD as a treatment for generalised anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder“ [4]
In a case series, including 72 people at a psychiatric clinic, involving the clinical application of CBD for anxiety and sleep complaints (as an adjunct to usual treatment) found positive findings. This published non-controlled study, highlighted that anxiety scores decreased within the first month in 79.2% in anxiety-prone patients (and remained reduced during the study duration). Sleep scores improved within the first month in 66.7% of the patients (though they fluctuated over time). CBD was well tolerated in all but 3 patients [5].
Interestingly, a single dose of CBD before a Simulation Public Speaking Test not only significantly decreased subjective anxiety symptoms but also reduced cognitive impairment, speech performance discomfort and alert in an anticipatory speech during, in comparison to the placebo group. The placebo (no CBD) group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the CBD group [5]

CBD enhanced extinction of fear memories in healthy volunteers: specifically, inhaled CBD administered before or after a fear conditioning program led to reduction of skin conductance response (sweating) and a significant reduction in shock ratings during further challenge [6]. Consider this benefit in those with anxiety related hyperhydrosis patients.
The mechanism by which CBD reduces the fear and shock response is likely because it stimulates a brain receptor, called 5-HT1A. The activation of this serotonin receptor may be why CBD improves several symptoms associated with post-traumatic stress disorder, including reducing acute heart rate and blood pressure, reducing arousal and avoidance of stress, and enhancing the blocking of intrusive persistent fear memories [3]. Serotonin support has other well known mood benefits.

Another report postulated that the acute anxiety-reducing effects of CBD in individuals with generalised social anxiety disorder come from its modification of cerebral blood flow in limbic and paralimbic areas (emotional centres in the brain). As a result of its 5-HT1A receptor upregulation, established in animal studies [8].

“Current evidence suggests CBD has the ability to reduce psychotic, anxiety and using symptoms by means of several hypothesised pharmacological properties”. [9] Larger studies were recommended.

For more information on the anti-inflammatory and antioxidative benefits see the 2019 article “Antioxidative and Anti-Inflammatory Properties of Cannabidiol” [10] The anti-inflammatory effect is largely invoked by activation of the endocannabinoid system, and there is evidence for its use in central, neuropathic pain. [11] although without THC the effects of CBD are moderate [12].

Evidence points toward a calming effect for CBD in the central nervous, and endocannabinoid systems assisting in many of the symptoms discussed above.
NanoCBD is a Practitioner Grade CBD with Active Target Delivery
The Benefits of Active Target Delivery
  • Standardised dosing with every batch
  • Improved absorption & pharmacokinetics
  • More effective benefits with smaller doses leading to fewer side effects
  • Faster delivery for better acute outcomes leading to better patient compliance & satisfaction